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Elevated systolic or diastolic pressure causes increased cardiovascular riskand the absolute risk increase per mmHg is greater at higher blood pressuresso that even modest reductions of severe hypertension can provide substantial benefitRelative risk reduction from blood pressure reduction is similar across populations with varying absolute riskso the absolute benefit is greater in patients who are at higher risk independent of their hypertensionfor examplepatients with diabetes or hyperlipidemiaand such patients would be expected to benefit from more aggressive treatment to a lower blood pressure goal.

Worsening of angina and acute myocardial infarctionMIcan develop after dose is started or increasedparticularly with severe obstructive CAD.

Co-administration with CYP3A inhibitorsmoderate and strongresults in increased systemic exposure to amlodipine and may require dose reductionmonitor for symptoms of hypotension and edema when amlodipine is co-administered with CYP3A inhibitors to determine the need for dose adjustment.

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