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Peginterferon alfa-2b minor monitor for adverse effects associated with increased exposure to triamterene if peginterferon alfa-2b is coadministered.

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Calcium excretion is decreased by thiazidesPathological changes in the parathyroid gland with hypercalcemia and hypophosphatemia have been observed in a few patients on prolonged thiazide therapyThe common complications of hyperparathyroidism such as renal lithiasisbone resorptionand peptic ulceration have not been seenThiazides cialis prices target. should be discontinued before carrying out tests for parathyroid function.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effectsMany people using this medication do not have serious side effects.

Gastrointestinaljaundiceintrahepatic cholestatic jaundicepancreatitisnauseaappetite disturbancetaste alterationvomitingdiarrheaconstipationanorexiagastric irritationcramping.

Triamterene inhibits the epithelial sodium channels on principal cells in the late distal convoluted tubule and collecting tubulewhich are responsible for 1-2of total sodium reabsorptionAs sodium reabsorption is inhibitedthis increases the osmolarity in the nephron lumen and decreases the osmolarity of the interstitiumSince sodium concentration is the main driving force for water reabsorptiontriamterene can achieve a modest amount of diuresis by decreasing the osmotic gradient necessary for water reabsorption from lumen to interstitiumTriamterene also has a potassium-sparing effectNormallythe process of potassium excretion is driven by the electrochemical gradient produced by sodium reabsorptionAs sodium is reabsorbedit leaves a negative potential in the lumenwhile producing a positive potential in the principal cellThis potential promotes potassium excretion through apical potassium channelsBy inhibiting sodium reabsorptiontriamterene also inhibits potassium excretion.

Hyperkalemia has been reported in diabetic patients with the use of potassium-conserving agents even in the absence of apparent renal impairmentAccordinglyMAXZIDEtriamterene and hydrochlorothiazideshould be avoided in diabetic patientsIf it is employedserum electrolytes must be frequently monitored.

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kidney disease, or if you are unable to urinate; high levels of potassium in your blood hyperkalemia ; or if you are taking potassium supplements or other potassium-sparing diuretics such as aldactazide, amiloride midamor, moduretic , or triamterene dyrenium, dyazide, maxzide .

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